@ARTICLE{Xu_H._Expression_2018,
 author={Xu, H. and Zhang, P. and Li, R. and Wu, W. and Wang, S. and Xu, Y.},
 volume={vol. 21},
 number={No 2},
 journal={Polish Journal of Veterinary Sciences},
 pages={343–351},
 howpublished={online},
 year={2018},
 publisher={Polish Academy of Sciences Committee of Veterinary Sciences},
 publisher={University of Warmia and Mazury in Olsztyn},
 abstract={Heterogeneous nuclear ribonucleoprotein K (hnRNP K), is a multifunctional protein that participates in a variety of regulatory processes of signal transduction and gene expression. To further characterize the significance of hnRNP K in different male germ cells, we investigated the expression profiles of hnRNP K at different developmental stages in pig and rat testes, and conducted a comparative analysis of expression patterns between these two species. In porcine testis development, both the mRNA and protein level of hnRNP K were down-regulated from 3 months to 8 months. However, the expression level of hnRNP K was abundant across the embryonic period in rats, and decreased gradually from 0 day post partum (dpp) to 14 dpp, then increased with the highest level presenting at 90 dpp. Immunolocalization analysis further confirmed the differential expression and localization of hnRNP K protein during testis development in pigs and rats. The results showed that hnRNP K was widely distributed in gonocytes, spermatogonia, sertoli cells and Leydig cells. The dynamic expression profile of hnRNP K may imply its crucial and potential roles in the development of the testis, which will provide a theoretical basis for the future study of molecular mechanism regulation of spermatogenesis.},
 type={Artykuły / Articles},
 title={Expression analysis of multifunctional RNA-binding protein hnRNP K during development of mammalian testis},
 URL={http://ochroma.man.poznan.pl/Content/106875/PDF/13.pdf},
 doi={10.24425/122603},
 keywords={hnRNP K, testis development, spermatogenesis, pig, rat},
}