@ARTICLE{Zań_R._Pharmacokinetics_2020,
 author={Zań, R. and Burmańczuk, A. and Stępień-Pyśniak, D. and Gajda, A. and Gbylik-Sikorska, M. and Posyniak, A. and Kowalski, C. and Grabowski, T.},
 volume={vol. 23},
 number={No 1},
 journal={Polish Journal of Veterinary Sciences},
 pages={43-50},
 howpublished={online},
 year={2020},
 publisher={Polish Academy of Sciences Committee of Veterinary Sciences},
 publisher={University of Warmia and Mazury in Olsztyn},
 abstract={To date, only a few studies on the azithromycin (AZM) pharmacokinetics in ornamental birds have been published. In the current study AZM concentrations in domestic pigeon (Columba livia domestica) plasma samples were analyzed using a validated ultra-high performance liquid chromatography tandem mass spectrometry method. The aim of the current study was to carry out an analysis of the pharmacokinetics and pharmacodynamics after administration of a single oral dose of a sustained-release AZM formulation and to conduct a simulation of treatment based on selected minimal inhibitory values. The study was performed with 12 healthy adult pigeons, both sexes. The pigeons tolerated AZM very well and no adverse effects were observed in any animal during the study. Based on the observed characteristics of the pharmacokinetics/ /pharmaco dynamics profiles of AZM in pigeons, it should be noted that 35 mg/kg per os as a single starting dose and 25 mg/kg every 24 h are recommended for treatment of both suscep- tible and less susceptible pathogens.},
 type={Article},
 title={Pharmacokinetics and pharmacodynamics of a single dose of sustained-release azithromycin formulation in pigeons},
 URL={http://ochroma.man.poznan.pl/Content/115987/PDF/06.pdf},
 doi={10.24425/pjvs.2020.132747},
 keywords={azithromycin, pigeon, pharmacokinetics, pharmacodynamics, dose},
}