@ARTICLE{Takamura_H._Comparison_2020,
 author={Takamura, H. and Chongphaibulpatana, P. and Uzuka, Y.},
 volume={vol. 23},
 number={No 4},
 journal={Polish Journal of Veterinary Sciences},
 pages={491-494},
 howpublished={online},
 year={2020},
 publisher={Polish Academy of Sciences Committee of Veterinary Sciences},
 publisher={University of Warmia and Mazury in Olsztyn},
 abstract={Canine status epilepticus (CSE) is characterized by epileptic seizures that are longer than 5 min or more than one seizure with incomplete recovery. Currently, diazepam suppositories are generally prescribed for CSE. Levetiracetam (LEV) is one of the newest antiepileptic drugs currently available. This study compared the pharmacokinetics of intragastric and intrarectal administration in oral formula of LEV in four healthy beagles as a reference data when the owner administers levetiracetam to dogs by himself at home. Blood for measuring plasma LEV concen- trations was collected 0, 30, 60, 90, 120, 240, 360, and 540 min after LEV administration. The time to reach the maximum plasma concentration (Tmax) was markedly shorter with intra- rectal administration (45±26 min) than with intragastric administration (270±99 min). Intrarectal administration of LEV tablets could be an effective option for treating canine seizures although it might be a limit for treating CSE because the absorption rate is not fast enough.},
 type={Article},
 title={Comparison of pharmacokinetics of intragastrically and intrarectally administered levetiracetam tablets in healthy non-epileptic dogs},
 URL={http://ochroma.man.poznan.pl/Content/117729/PDF/2.pdf},
 doi={10.24425/pjvs.2020.134697},
 keywords={canine status epilepticus, dogs, intragastric administration, intrarectal administration, levetiracetam, pharmacokinetics},
}