Title

Pharmacokinetics of tramadol and metabolites after injective administrations in dogs

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2010

Issue

No 4

Authors

Łebkowska-Wieruszewska, B. ; Giorgi, M. ; Kowalski, C. ; S. Del Carlo ; Saccomanni, G.

Divisions of PAS

Nauki Biologiczne i Rolnicze

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Date

2010

Identifier

DOI: 10.2478/v10181-010-0027-y ; ISSN 1505-1773

Source

Polish Journal of Veterinary Sciences; 2010; No 4

References

A. de Sousa (2008), Pharmacokinetics of tramadol and o-desmethyltramadol in goats after intravenous and oral administration, J Vet Pharmacol Ther, 31, 45. ; Elghazali M. (2008), The pharmacokinetics, metabolism and urinary detection time of tramadol in camels, Vet J, 178, 272. ; Garrido M. (2003), Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity, J Pharmacol Exp Ther, 305, 710. ; Giorgi M. (2009a), Pharmacokinetics of tramadol and its major metabolites following rectal and intravenous administration in dogs, N Z Vet J, 57, 146. ; Giorgi M. (2009b), Pharmacokinetic and urine profile of tramadol and its major metabolites following oral immediate release capsules administration in dogs, Vet Res Commun, 33, 875. ; Giorgi M. (2009c), Pharmacokinetics of tramadol and its metabolites M1, M2 and M5 in donkeys following intravenous and oral immediate release single dose administration, J Equine Vet Sci, 29, 569. ; Giorgi M. (2009d), Pharmacokinetic evaluation of tramadol and its major metabolites after single oral sustained tablet administration in the dog: a pilot study, Vet J, 180, 253. ; Giorgi M. (2007), Pharmacokinetics of tramadol and its metabolites M1, M2 and M5 in horses following intravenous, immediate release (fasted/fed) and sustained release single dose administration, J Equine Vet Sci, 27, 481. ; Grond S. (1999), Serum concentrations of tramadol enantiomers during patient-controlled analgesia, Br J Clin Pharmacol, 48, 254. ; Grond S. (2004), Clinical pharmacology of tramadol, Clin Pharmacokinet, 43, 879. ; Kukanich B. (2004), Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs, J Vet Pharmacol Ther, 27, 239. ; Lintz W. (1999), Bioavailability of tramadol after i.m. injection in comparison to i.v. infusion, Int J Clin Pharmacol Ther, 37, 175. ; McMillan C. (2008), Pharmacokinetics of intravenous tramadol in dogs, Can J Vet Res, 72, 325. ; Pypendop B. (2008), Pharmacokinetics of tramadol, and its metabolite O-desmethyl-tramadol, in cats, J Vet Pharmacol Ther, 31, 52. ; Raffa R. (1992), Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an ‘atypical’ opioid analgesic, J Pharmacol Exp Ther, 260, 275. ; Shilo Y. (2008), Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration, J Vet Pharmacol Ther, 31, 60. ; Shipton E. (2000), Tramadol - present and future, Anaesth Intensive Care, 28, 363.