Title

Effect of deoxynivalenol on the levels of toll-like receptors 2 and 9 and their mRNA expression in enterocytes in the porcine large intestine: a preliminary study

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2017

Issue

No 2

Authors

Dąbrowski, M. ; Jakimiuk, E. ; Gajęcka, M. ; Gajęcki, M.T. ; Zielonka, Ł.

Divisions of PAS

Nauki Biologiczne i Rolnicze

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Date

2017

Identifier

DOI: 10.1515/pjvs-2017-0026 ; ISSN 1505-1773

Source

Polish Journal of Veterinary Sciences; 2017; No 2

References

Pinton (2014), IP Effect of deoxynivalenol and other Type trichothecenes on the intestine a Toxins, review, 1615. ; Tohno (2005), like receptor is expressed on the intestinal cells in swine, Biochem Biophys Res Commun, 330. ; Fink (1999), their implications for human and animal Vet, health, 21, 115. ; Sánchez (2011), Transcript levels of Toll - Like Receptors correlate with inflammatory activity in Ulcerative Colitis, BMC Gastroenterol, 8, 5. ; Burkey (2009), Expression of porcine Toll - like receptor gene transcripts in the presence of lipopolysaccharide and Salmonella enterica serovars Typhimurium and Vet, null, 4. ; Latz (2004), signals after translocating from the ER to CpG DNA in the lysosome, Nat Immunol, 190. ; Rodrigues (2012), three - year survey on the worldwide occurrence of mycotoxins in feedstuffs and feed Toxins, null, 663. ; Bryden (2007), in the food chain human implications, health Asia Pac J Clin Nutr, 16, 1. ; Pestka (2010), mechanisms of action human exposure and toxicological relevance, Arch Toxicol, 663. ; Patterson (2008), The pig as an experimental model for elucidating the mechanisms governing dietary influence on mineral absorption, Exp Biol Med, 233. ; Pestka (2005), AT and potential effects on humans, toxicology Toxicol Environ Health Crit Rev, 8. ; Rachmilewitz (2002), Leider Immunostimulatory DNA ameliorates experimental and spontaneous murine colitis, Gastroenterology, 122. ; Cario (2007), - like receptor controls mucosal inflammation by regulating epithelial barrier function, Gastroenterology, 132. ; Abysique (null), The food contaminant mycotoxin deoxynivalenol inhibits the swallowing reflex in anaesthetized rats One, null, 2015. ; Zwierzchowski (2004), The occurrence of zearalenone and its derivatives in standard and therapeutic feeds for companion animals, Pol J Vet Sci, 289. ; Piotrowska (2014), The effect of experimental fusarium mycotoxicosis on microbiota diversity in porcine ascending colon contents Toxins, null, 2064. ; Rose (2012), nd CA is important for protection against intestinal damage and for intestinal repair, Sci Rep, 574. ; Feinberg (1989), Biochemical mechanism of action of tricothecene mycotoxins In ed Pathological Effects, null, 27. ; Camilleri (2007), Intestinal permeability and irritable bowel syndrome Neurogastroenterol, null, 19, 545. ; Li (2008), Comparative induction of ribosomal RNA cleavage by ricin and the trichothecenes deoxynivalenol toxin in the macrophage, Toxicol Sci, 28, 67. ; Shifrin (1999), VI Trichothecene mycotoxins trigger a ribotoxic stress response that activates terminal kinase and mitogen - activated protein kinase and induces apoptosis, J Biol Chem, 274. ; Obermeier (2002), motifs of bacterial DNA exacerbate colitis of dextran sulfate sodium - treated mice, Eur J Immunol, 2084. ; Uddin (2013), Expression patterns of porcine Toll - like receptors family set of genes in gut - associated lymphoid tissues alter with age, Res Vet Sci, 95, 1. ; Chung (2003), Transcriptional and posttranscriptional roles for mitogen - activated protein kinase in upregulation of TNF - alpha expression by deoxynivalenol vomitoxin, Appl Pharmacol, 193. ; (2006), EC Commision recomendation on the presence of deoxynivalenol zearalenone ochratoxin and fumonisins in products intended for animal feeding Official of the European Union http eur lex europa eu legal content EN TXT uri CELEX, Journal, 229. ; Wetzler (2003), The role of Toll like receptor in microbial disease and immunity, Vaccine, 21. ; Kassinen (2007), The fecal microbiota of irritable bowel syndrome patients differs significantly from that of healthy subjects, Gastroenterology, 133. ; Kolf (2009), IP of a pig jejunal explant culture for studying the gastrointestinal toxicity of the mycotoxin deoxynivalenol : histopathological analysis In, Development Toxicol Vitro, 23, 1580. ; Middlebrook (1989), Binding of toxin to eukaryotic cell ribosomes, Biochem Pharmacol, 3103. ; Akira (2004), like receptor signaling, Nat Rev Immunol, 499. ; Taranu (null), Induction of pro - inflammatory gene expression by Escherichia coli and mycotoxin zearalenone contamination and protection by a Lactobacillus mixture in porcine IPEC cells, Toxicon, 97, 2015. ; Cario (2010), like receptors in inflammatory bowel diseases : a decade later, Inflamm Bowel Dis, 16, 1583. ; Binder (2007), EM Managing the risk of mycotoxins in modern feed production Feed, Sci Technol, 133. ; Czerwiecki (2004), columns and determination of ochratoxin A in cereals by HPLC Part evaluation of extraction using methanol / water, null, 133. ; Wiśniewska (1999), Determination of fumonisins in corn and fodder by liquid chromatography, Med Weter, 114. ; Uenishi (2009), Porcine Toll - like receptors : the front line of pathogen monitoring and possible implications for disease resistance, Dev Comp Immunol, 353. ; He (2010), - induced modulation of microRNA expression in RAW macrophages potential novel mechanism for translational inhibition Toxicologist, Toxicol Sci, 264. ; Pestka (2006), - like receptor priming sensitizes macrophages to proinflammatory cytokine gene induction by deoxynivalenol and other toxicants, Toxicol Sci, 445. ; Zhou (2003), AS Role of double - stranded RNA - activated protein kinase in deoxynivalenol - induced ribotoxic stress response, Toxicol Sci, 335. ; Sergent (2006), Deoxynivalenol transport across human intestinal Caco cells and its effects on cellular metabolism at realistic intestinal concentrations, Toxicol Lett, 164. ; Sugiyama (2016), κB activation via dependent Toll - like receptor signaling is inhibited by trichothecene mycotoxin deoxynivalenol, J Toxicol Sci, 273. ; Brint (2011), EM Differential expression of toll - like receptors in patients with irritable bowel syndrome, Am J Gastroenterol, 106. ; Bouhet (2005), IP The effects of mycotoxins fungal food contaminants on the intestinal epithelial cell - derived innate immune response Vet, null, 108. ; Hausmann (2002), like receptors are up - regulated during intestinal inflammation, Gastroenterology, 122. ; Shimosato (2005), - like receptor is expressed on follicle - associated epithelia containing cells in swine Peyer s patches, Immunol Lett, 98, 83. ; Meurens (2012), The a model for human infectious diseases, Trends Microbiol, 20. ; Iordanov (1997), BE Ribotoxic stress response : activation of the stress - activated protein kinase JNK by inhibitors of the peptidyl transferase reaction and by sequence - specific RNA damage to the alpha - sarcin / ricin loop in the rRNA, Mol Cell Biol, 28, 1.