Title

In vitro evaluation of zearalenone toxicity by comet assay

Journal title

Polish Journal of Veterinary Sciences

Yearbook

2022

Volume

vol. 25

Issue

No 3

Affiliation

Harcarova, M. : Department of Animal Nutrition and Husbandry, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic ; Conkova, E. : Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic ; Kolenicova, S. : Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic ; Holeckova, B. : Department of Biology and Physiology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic ; Proskovcova, M. : Department of Pharmacology and Toxicology, University of Veterinary Medicine and Pharmacy in Kosice, Komenskeho 73, 041 81 Kosice, Slovak Republic

Authors

Harcarova, M. ; Conkova, E. ; Kolenicova, S. ; Holeckova, B. ; Proskovcova, M.

Keywords

mycotoxins ; toxicity ; comet assay

Divisions of PAS

Nauki Biologiczne i Rolnicze

Coverage

475-477

Publisher

Polish Academy of Sciences Committee of Veterinary Sciences ; University of Warmia and Mazury in Olsztyn

Bibliography

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Collins AR (2004) The comet assay for DNA damage and repair. Principles, applications, and limitations. Mol Biotechnol 26: 249-261.
Gao F, Jiang LP, Chen M, Geng CY, Yang G, Ji F, Zhong LF (2013) Genotoxic effects induced by zearalenone in a human embryonic kidney cell line. Mutat Res 755: 6-10.
Jackson SP (2002) Sensing and repairing DNA double-strand breaks. Carcinogenesis 23: 687-696.
Kachlek M, Szabó-Fodor J, Blochné Bodnár Z, Horvatovich K, Kovács M (2017) Preliminary results on the interactive effects of deoxynivalenol, zearalenone and fumonisin B1 on porcine lymphocytes. Acta Vet Hung 65: 340-353.
Klarić MŠ, Daraboš D, Rozgaj R, Kašuba V, Pepeljnjak S (2010) Beauvericin and ochratoxin A genotoxicity evaluated using the alkaline comet assay: single and combined genotoxic action. Arch Toxicol 84: 641-650.
Koleničová S, Holečková B, Galdíková M, Schwarzbacherová V, Drážovská M (2021) Genotoxicity testing of bovine lymphocytes exposed to epoxicon-azole using alkaline and neutral comet assay. Caryologia 11: 99-109.
Końca K, Lankoff A, Banasik A, Lisowska H, Kuszewski T, Góźdź S, Koza Z, Wojcik A (2003) A cross-platform public domain PC im-age-analysis program for the comet assay. Mutat Res 534: 15-20.
Marin DE, Taranu I, Burlacu R, Manda G, Motiu, M, Neagoe I, Dragomir C, Stancu, M, Calin L (2011) Effects of zearalenone and its deriva-tives on porcine immune response. Toxicol In Vitro 25: 1981-1988.
Reddy KE, Song J, Lee HJ, Kim M, Kim DW, Jung HJ, Kim B, Lee Y, Yu D, Kim DW, Oh YK, Lee SD (2018) Effects of high levels of deoxynivalenol and zearalenone on growth performance, and hematological and immunological parameters in pigs. Toxins (Basel) 10: 114.
Szabo RT, Kovács-Weber M, Erdélyi M, Balogh K, Fazekas N, Horváth Á, Mézes M, Kovács B (2019) Comet assay study of the genotoxic effect of T-2 and HT-2 toxins in chicken hepatocytes. Biol Fut 70: 330-335.
Thapa A, Horgan KA, White B, Walls D (2021) Deoxynivalenol and zearalenone-synergistic or antagonistic agri-food chain co-contaminants? Toxins (Basel) 13: 561.

Date

2022.09.21

Type

Short communication

Identifier

DOI: 10.24425/pjvs.2022.142033