Medical sciences

Folia Medica Cracoviensia

ISSN

ISSN 0015-5616

Publishers

Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum

Editorial Board:

Editor-in-Chief
dr hab. Krzysztof Gil, prof. UJ, Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0002-4732-7698

Vice Editor-in-Chief
Prof. Andrzej Surdacki, 2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-7949-3140

Secretary Editor
Prof. Beata Kuśnierz – Cabala, Department of Diagnostics, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-8639-5688

Editorial Board Members:

Prof. Benjamin Chain, Department of Infection and Immunity, University College London, London, England

Prof. Paul Enck, Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen Germany

Prof. Tomasz Grodzicki, Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Kraków, Poland

Prof. Kalina Kawecka-Jaszcz, 1st Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland

Prof. Maciej Małecki, Department of Metabolic Diseases, Jagiellonian University Medical College, Kraków, Poland

Prof. Janusz Marcinkiewicz, Department of Immunology, Jagiellonian University Medical College, Kraków, Poland

Prof. Franz H. Messerli, Swiss Cardiovascular Center, University of Bern, Switzerland and Department of Cardiology, Icahn School of Medicine, Mount Sinai Health Center, New York, USA

Prof. Jacek Musiał, 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland

Prof. Wiesław Pawlik, Department of Physiology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jacek J. Pietrzyk, 1st Department of Children's Diseases and the Department of Pediatrics, Jagiellonian University Medical College, Kraków, Poland

Prof. Władysław Sułowicz, Department of Nephrology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jerzy A. Walocha, Department of Anatomy, ,Jagiellonian University Medical College, Kraków, Poland

Adres redakcji
ul. Czysta 18
31-121 Kraków
e-mail: folmedcrac@pan.pl

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Content

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3

1 The Inhibitory Effect of Human Plasma Albumin and Haptoglobin on Platelet Aggregation and 5-HT Release

Nadia Khan , Magdalena Kurnik-Łucka , Gniewomir Latacz , Krzysztof Gil , Sheikh Arshad Saeed

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 5-16 | DOI: 10.24425/fmc.2022.142365

Keywords: human plasma endogenous inhibitor of platelet aggregation (EIPA) arachidonic acid metabolism affinity chromatography albumin haptoglobin

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Abstract

Platelet aggregation contributes to the pathogenesis of cardiovascular diseases. After activation it leads to dense granule secretion and 5-HT release. The question arises; how platelet aggregation is endogenously controlled during blood circulation. In preliminary studies, we observed that human plate-lets aggregate more rapidly when suspended in buffer as compared to those suspended in plasma (PRP). These observations point to the presence of an endogenous substance that may inhibit arachidonic acid– induced platelet aggregation. An analysis of plasma Cohn fractions demonstrated that most of the plasma inhibitory activity was associated with albumin–rich and α-globulin rich protein fractions. The identity of plasma endogenous inhibitors of platelet aggregation (EIPA) was established by affinity chromatography on Cibacron Blue F3G-A for specific removal of albumin. The association of α-globulins to EIPA activity was recognized as due to haptoglobin by affinity chromatography on a column of hemoglobin-sepharose. In addition, we also found that the distribution of EIPA activity varies according to sex and physiological state. These findings reveal that EIPA may act by modulation of arachidonic acid metabolism or seques-tering the fatty acid substrate.

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Authors and Affiliations

Nadia Khan

1 2 3

Magdalena Kurnik-Łucka

Gniewomir Latacz

Krzysztof Gil

Sheikh Arshad Saeed

Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), University of Karachi, Karachi, Pakistan
Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
Department of Technology & Biotechnology of Drugs, Faculty of Pharmacy, Jagiellonian University Medical College, Kraków, Poland

2 Anesthesia for gynecological cancer surgery

Paweł Krawczyk , Tomasz Lonc , Rafał Świstek , Paweł Tyszecki , Janusz Andres

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 19-42 | DOI: 10.24425/fmc.2022.142366

Keywords: regional anesthesia general anesthesia gynecological oncology robotic surgery review

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Abstract

Malignant neoplasms are currently a severe medical challenge and the second leading cause of death worldwide. The modern anesthesia applied may improve the patient outcome. This paper presents a review of anesthesia management related to patients with gynaecologic malignancies. It includes the influence of the type of anesthesia on cancer recurrence, application of regional anesthesia in gynaecologic oncologic surgery, and selected aspects of anesthesia for robotic surgery. We performed a literature search on MEDLINE, EMBASE, Google Scholar, the Cochrane Central Register of Controlled Trials, and Clinical Trials. The database search focused on the topics related to anesthesia in gynecological oncology. The authors also contributed through individual, independent literature searches.

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Authors and Affiliations

Paweł Krawczyk

Tomasz Lonc

Rafał Świstek

Paweł Tyszecki

Janusz Andres

Department of Anesthesiology and Intensive Care Medicine, Jagiellonian University Medical College, Kraków, Poland
Department of Anesthesiology and Intensive Care Medicine 5th Military Hospital with Polyclinic Kraków, Poland

3 Risk factors for the development of temporomandibular disorders related to the work environment — a literature review and own experience

Małgorzata Pihut , Magdalena Orczykowska , Andrzej Gala

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 43-49 | DOI: 10.24425/fmc.2022.142367

Keywords: temporomandibular disorders TMD work environment pain of the temporomandibular joints stress emotional tension

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Abstract

This article characterizes the etiology of temporomandibular disorder with particular emphasis on emotional factors that have a major impact on the development of these dysfunctions and the most common their symptoms. They mainly affect people in the third and fourth decade of life and women predominate among this group of patients.
The article analyzes the current literature (Pub Med Database, Scopus and EMBASE) in relation to the conditions in the work environment, which often constitute important causes of emotional tensions, constant state of mental tension and susceptibility to the effects of stressors, which have an impact on the state of functioning of the musculoskeletal system of the masticatory system.
Despite the high frequency of temporomandibular disorders, unfortunately only a few studies describe the influence of harmful factors related to the work environment, and own experience (information from the patient’s interview) and data from the literature indicate a significant share of these factors in the devel-opment of temporomandibular disorder. The relationships and anatomical connections affecting the influence of stressors on the functioning of masticatory muscles and temporomandibular joints are also discussed. In conclusion, it should be stated that the work environment and the emotional tensions generated in it constitute a serious sociological problem and increase the risk of developing and intensify the symptoms of TMD.

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Authors and Affiliations

Małgorzata Pihut

Magdalena Orczykowska

Andrzej Gala

Prosthodontic and Orthodontic Department, Dental Institute, Jagiellonian University Medical College, Kraków, Poland

4 Modulating the activity of fluoropyrimidines against colorectal cancer by Vitamin D and its analogs

Michał Jurczyk , Aleksandra Midro , Magdalena Król , Weronika Olesiak , Dariusz Stąpor , Anna Gil , Krzysztof Gil

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 51-62 | DOI: 10.24425/fmc.2022.142368

Keywords: vitamin D colorectal cancer 5-fluorouracil fluoropyrimidines

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Abstract

Colorectal cancer (CRC) is the third most common malignancy worldwide and the second most deadly cancer. Scientists have projected that by 2040, the prevalence will reach up to 3.2 million new cases annually due to population aging, disadvantageous diet transformations, and elevated exposure to risk factors. In the past decades, the five-year survival rate in colorectal cancer has significantly increased to 65% due to the development of an early endoscopic diagnosis and new chemotherapeutic approaches. Fluoropyrimidines, such as 5-fluorouracil or capecitabine, are commonly used to treat CRC. One of the most fundamental mechanisms of 5-FU is based on the inhibition of thymidylate synthase. This action is responsible for the therapeutic, but also toxic, effects of the drug. In this short review, we discuss the possible effects of vitamin D activity on colorectal cancer cells in relation to fluoropyrimidines. PubMed, Embase, and Web of Science databases were searched up to January 2022 for studies on vitamin D and 5-fluorouracil interaction mechanisms. Original studies, case reports, and review articles were included.
Vitamin D or its analogs target multiple biochemical pathways and modulate numerous pathophysiolo-gical mechanisms in the course of colon cancer, including those related to the pharmacological sites of fluoropyrimidines. However, the available data concerning vitamin D–fluoropyrimidine pharmacological interactions are limited, especially regarding patients suffering from colon cancer and being treated with fluoropyrimidines.

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Authors and Affiliations

Michał Jurczyk

Aleksandra Midro

Magdalena Król

Weronika Olesiak

Dariusz Stąpor

Anna Gil

Krzysztof Gil

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland

5 Total ankle arthroplasty with the use of Zimmer prosthesis and a review of the results of previous research conducted in this field

Artur Fałek , Szymon Skwarcz , Artur Staszczuk , Marek Paździor

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 63-78 | DOI: 10.24425/fmc.2022.142369

Keywords: ankle arthrodesis contraindications total ankle replacement ankle degenerative disease lateral access

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Abstract

The aim of this article is to describe surgical technique and early results of Total Ankle Replacement (TAR) from lateral approach using Zimmer TM prosthesis. The study uses theoretical knowledge which is the result of research conducted by other authors, and practical knowledge due to the fact that our center performs that type of operation. Arthrodesis as the current standard in the treatment of advanced degenerative ankle disease, apart from its advantages, also has many disadvantages. The relative durability and reduction of the patient’s pain have been achieved at the expense of the adjacent joints. Their accelerated arthrosis is the result of compensatory loads as a consequence of change in foot biomechanics. That determined implementation of solutions that will guarantee elimination of pain in the ankle joint, preserve its motor function and improve gait, while having no negative impact on the mobility of adjacent joints.

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Authors and Affiliations

Artur Fałek

Szymon Skwarcz

Artur Staszczuk

Marek Paździor

Department of Trauma and Orthopedic Surgery and Spine Surgery, Independent Public Healthcare, Puławy, Poland

6 Physiotherapeutic rehabilitation of adolescent patients with temporomandibular disorders

Małgorzata Pihut , Elżbieta Zarzecka-Francica , Andrzej Gala

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 79-90 | DOI: 10.24425/fmc.2022.142370

Keywords: temporomandibular disorder physiotherapy manual therapy kinesitherapy adolescent

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Abstract

TMD is a group of pathological changes including increased tension in the masticatory muscles, pain in the muscles and/or the temporomandibular joints, abnormal range of the mandibular movement or the presence of acoustic symptoms in the joints in the form of clicking or poping. The aim of the project was to compare the effectiveness of two methods of physiotherapeutic rehabilita-tion, used in adolescent patients with temporomandibular disorders.
Material and Methods: The material consisted of 68 patients, aged 14 to 17, of both sexes, generally healthy, who came to the Dental Prosthetics Department for treatment due to pain in the masticatory muscles. Dental examination and diagnostics revealed Ia in all cases in accordance with RDC/TMD protocol. Manual therapy was performed in group I (34 people) and kinesitherapy with massage was performed in group II (34 people). Patients were allocated randomly to both groups. Contraindications were considered for both methods.
Results: Within the first study, mean values of pain intensity between group I and group II were not significantly different (6.12 and 6.24 respectively). Within the second study significantly lower VAS scores in both groups have been revealed (0.92 and 0.74 respectively). Results of the first and second study differed significantly in both groups. Similar results were obtained for the maximum abduction of the mandible.
Conclusions: The results of the conducted studies indicate a beneficial effect of the assessed phy-siotherapeutic procedures in terms of functional rehabilitation of adolescent patients with temporoman-dibular disorders.

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Authors and Affiliations

Małgorzata Pihut

Elżbieta Zarzecka-Francica

Andrzej Gala

Prosthodontics and Orthodontics Department, Dental Institute, Jagiellonian University Medical College, Kraków, Poland

7 The challenging diagnosis of acute scrotum: remaining difficulties and further insights

Ioanna Gkalonaki , Ioannis Patoulias , Michail Anastasakis , Christina Panteli , Dimitrios Patoulias

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 91-100 | DOI: 10.24425/fmc.2022.142371

Keywords: acute scrotum spermatic cord torsion acute epididymitis appendiceal torsion

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Abstract

The main target during management of a male pediatric patient with clinical signs of acute scrotum is the timely diagnosis, in order not to jeopardize the viability of the affected testicle. Thorough evaluation of the patient’s medical history, symptomatology, clinical and ultrasonographic findings, con-stitutes the basis of the diagnostic procedure. After comprehensive research of the relevant literature, we highlight the remaining difficulties in the evaluation of the clinical and ultrasonographic findings for the accurate diagnosis of the acute scrotum. In conclusion, it is worth emphasizing on the following: a. the most common diseases that come under the diagnosis of the acute scrotum may present with similar symptoms, b. in neglected cases the diagnostic approach becomes more difficult, constituting the evalua-tion of the pathognomonic clinical signs challenging, and c. inability to exclude the diagnosis of spermatic cord torsion should be an indication for the surgical exploration of the affected hemiscrotum.

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Authors and Affiliations

Ioanna Gkalonaki

e-mail:

ORCID:

Ioannis Patoulias

Michail Anastasakis

Christina Panteli

Dimitrios Patoulias

First Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “G. Gennimatas”, Thessaloniki, Greece
First Department of Internal Medicine, General Hospital “Hippokration”, Thessaloniki, Greece

8 Notes about telocytes and immunity

Veronika Aleksandrovych , Anna Gil , Adrian Poniatowski

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 101-109 | DOI: 10.24425/fmc.2022.142373

Keywords: immune response telocytes interleukins cytokines macrophages

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Abstract

The interstitial cells known as telocytes have been described in various organs. Their role in the normal physiology and pathogenesis of numerous diseases is well known. They have been described in the context of various diseases (gallstone disease, endometriosis, uterine myoma, hydronephrosis, myocardial infraction, psoriasis, etc.), while their impact on inflammation, involvement in angiogenesis, and repair highlights their part in local homeostasis. What is known about their relationship with the immune system? Their secretomes, genome, immune profiles, contacts with surrounding cells, and specific loca-lization allow us to give a possible explanation for their involvement in pathological pathways. This review aims to present the roles and features of telocytes in the context of intestinal immunity (the largest in our body), in the spleen, their interactions with immunocytes, and their place in stem cell niches.

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Authors and Affiliations

Veronika Aleksandrovych

Anna Gil

Adrian Poniatowski

1 3

Department of Pathophysiology, Jagiellonian University Medical College, ul. Czysta 18, 31-121 Kraków, Poland
Department of Anatomy, Jagiellonian University Medical College, ul. Kopernika 12, 31-034 Kraków, Poland
Vassar Brothers Medical Center, Department of Medicine, 45 Reade Place, Poughkeepsie, NY, USA

9 Effect of acute hyperglycemia on baroreflex sensitivity in healthy young adults

Navkiran Ranjan , Kiran Prakash , Anita S. Malhotra

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3 | 111-122 | DOI: 10.24425/fmc.2022.142374

Keywords: spectral sequence beat-to-beat blood pressure electrocardiogram

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Abstract

Background: Autonomic dysfunction, impaired baroreflex sensitivity (BRS), and deranged circulatory homeostasis have been observed in chronic hyperglycemia and found to be associated with increased cardiovascular morbidity and mortality. However, the acute effects of hyperglycemia in healthy subjects have been rarely studied. The present study explores the effect of acute hyperglycemia on con-ventional and unconventional parameters of BRS in healthy young adults.
Methods: For the estimation of BRS beat-to-beat blood pressure (BP) and electrocardiogram were recorded in forty-two young, healthy subjects during fasting and at 1hr of the oral glucose load. Analysis of BRS was carried out by sequence and spectral method. Number of UP-, DOWN- and ALL-sequences between ramps of BP and RR-interval were calculated as an unconventional measure of BRS along with the other conventional parameters.
Results: We observed significant alteration of unconventional parameters of autonomic functions [the number of sequences of UP- (p = 0.0039) and ALL-sequences (p = 0.0233) of systolic BP and RR interval; and, UP- (p = 0.0380), DOWN- (p = 0.0417) and ALL-sequences (p = 0.0313) of mean BP and RR- interval] during acute hyperglycemia as compared to the fasting state. However, no significant changes were observed in any of the conventional parameters of BRS during acute hyperglycemia as compared to the fasting state.
Conclusions: Present study concludes that the unconventional parameters of BRS — the number of sequences between the ramp of BP and RR-interval — change significantly during acute hyperglycemia. However, the conventional parameters do not show significant changes during acute hyperglycemia. We may hypothesize that the relatively constant BRS is maintained at the expense of increased oscillations in the ramp of BP and RR-interval.

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Authors and Affiliations

Navkiran Ranjan

Kiran Prakash

Anita S. Malhotra

Department of Physiology, Government Medical College and Hospital, Chandigarh, India

10 Contents

Folia Medica Cracoviensia | 2022 | Vol. 62 | No 3

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Instructions for authors

Manuscripts will be considered for publication in the form of Original Articles or Reviews. Submitted work must comply with ethical policy, which is based on the Committee on Publication Ethics (COPE) guidelines on good publication. (http://publicationethics.org/). Only manuscripts that are previously unpublished, and are not offered simultaneously elsewhere will be considered.
SUBMISSION
Folia Medica Cracoviensia only accepts electronic submission via e-mail at folmedcrac@pan.pl. Manuscripts will be assigned a unique manuscript number that must be quoted in correspondence. Papers and Reviews are refereed by experts in the field; the Editors reserve the right to reject an article without review. Please submit your covering letter or comments to the Editor as well as the names of two potential referees (including name, affiliation, and e-mail address). Currently, Authors have the only option to publish their articles in printed version. The online version will be available soon.
Original Articles
Original Articles describe the results of basic or clinical studies. The length of all Original Articles is limited to 6000 words, excluding acknowledgements and disclosures, references, tables, figures, table legends and figure legends. Please limit the number of figures and tables to a maximum of eight (e.g. four figures and four tables). Color figures can be included as necessary; however authors will be charged a fee (for details please contact editorial office).
Review Articles
Topical reviews of basic or clinical areas are invited by the Editor. Manuscript length is limited to 5000 words and 50 references. All Review articles are subject to review.
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The Folia Medica Cracoviensia uses American spelling. Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English.

The complete set of instructions for Authors can be downloaded here as a PDF file: http://www.fmc.cm-uj.krakow.pl/pdf/Author_Guidelines_Folia_2017_Jul_31_KG1.pdf