Nauki Medyczne

Folia Medica Cracoviensia

ISSN

ISSN 0015-5616

Wydawcy

Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum

Editorial Board:

Editor-in-Chief
dr hab. Krzysztof Gil, prof. UJ, Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0002-4732-7698

Vice Editor-in-Chief
Prof. Andrzej Surdacki, 2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-7949-3140

Secretary Editor
Prof. Beata Kuśnierz – Cabala, Department of Diagnostics, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-8639-5688

Editorial Board Members:

Prof. Benjamin Chain, Department of Infection and Immunity, University College London, London, England

Prof. Paul Enck, Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen Germany

Prof. Tomasz Grodzicki, Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Kraków, Poland

Prof. Kalina Kawecka-Jaszcz, 1st Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland

Prof. Maciej Małecki, Department of Metabolic Diseases, Jagiellonian University Medical College, Kraków, Poland

Prof. Janusz Marcinkiewicz, Department of Immunology, Jagiellonian University Medical College, Kraków, Poland

Prof. Franz H. Messerli, Swiss Cardiovascular Center, University of Bern, Switzerland and Department of Cardiology, Icahn School of Medicine, Mount Sinai Health Center, New York, USA

Prof. Jacek Musiał, 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland

Prof. Wiesław Pawlik, Department of Physiology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jacek J. Pietrzyk, 1st Department of Children's Diseases and the Department of Pediatrics, Jagiellonian University Medical College, Kraków, Poland

Prof. Władysław Sułowicz, Department of Nephrology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jerzy A. Walocha, Department of Anatomy, ,Jagiellonian University Medical College, Kraków, Poland

Adres redakcji
ul. Czysta 18
31-121 Kraków
e-mail: folmedcrac@pan.pl

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- Vol. 63
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Zawartość

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3

1 The venous plexus of Rektorzik — anatomo-clinical issues retrieved from the literature data

Janusz Skrzat , Grzegorz Goncerz

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 5-13 | DOI: 10.24425/fmc.2023.147211

Słowa kluczowe: venous plexus of Rektorzik pericarotid venous plexus internal carotid venous plexus plexus venosus caroticus internus

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Abstrakt

The venous plexus of Rektorzik is a network of small veins, which enlace outside the wall of the internal carotid artery while it traverses the petrous part of the temporal bone. The anatomical and clinical issues related to the communication between the plexus of Rektorzik and other cranial venous structures were discussed in this paper.

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Autorzy i Afiliacje

Janusz Skrzat

Grzegorz Goncerz

Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland

2 Serum level of lactadhedrin (MFGE8) in inflamatory bowel disease

Kamil Kozioł , Danuta Owczarek , Dorota Cibor , Małgorzata Zwolińska-Wcisło

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 15-29 | DOI: 10.24425/fmc.2023.147212

Słowa kluczowe: MFGE8 lactadherin inflammatory bowel disease IBD

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Abstrakt

Objective: Evaluation of serum lactadherin level, its correlation with disease activity and certain biochemical parameters in IBD patients.
Methods: The study involved adult IBD patients, comprising 50 with ulcerative colitis (UC), 68 with Crohn’s disease (CD), and 29 healthy controls.
Results: The MFGE8 median concentration was significantly higher in UC versus controls (1914.54 vs. 1392.21; p = 0.017), but not in CD. The median MFGE8 levels in UC and CD patient groups didn’t significantly differ. There was a significant inverse correlation between MFGE8 and CRP (r = –0.283; p = 0.044) and fibrinogen (r = –0.362, p = 0.017) in UC. In active UC, MFGE8 median concentration was higher versus controls (1974.36 vs. 1392.21; p = 0.04) and negatively correlated with CRP (r = –0.482; p = 0.005), WBC (r = –0.391; p = 0.027), and fibrinogen (r = –0.473; p = 0.015). Inactive UC showed negative correlation only with fibrinogen (r = –0.567; p = 0.018). No correlations were found with disease activity measured using appropriate scales, age, BMI, or gender.
Conclusions: Active UC patients show higher MFGE8 levels. These increase inversely with inflamma-tory markers (CRP, WBC, fibrinogen) in active UC, but not in CD.

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Autorzy i Afiliacje

Kamil Kozioł

Danuta Owczarek

Dorota Cibor

Małgorzata Zwolińska-Wcisło

Department of Gastroenterology and Hepatology, Jagiellonian University Medical College, Kraków, Poland

3 Treatment Options for Tennis Elbow — An Umbrella Review

Michał Bonczar , Patryk Ostrowski , Dawid Plutecki , Martyna Dziedzic , Jakub Florek , Weronika Michalik , Wojciech Przybycień , Paweł Depukat , Bartosz Rutowicz , Ewa Walocha , Mateusz Koziej

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 31-58 | DOI: 10.24425/fmc.2023.147213

Słowa kluczowe: tennis elbow lateral epicondylitis lateral elbow pain treatment orthopedics surgery

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Abstrakt

Introduction: The main goal of the present umbrella review was to provide the most up-to- date and evidence-based results regarding the various treatment options for tennis elbow (TE), which hopefully will significantly decrease the confusions existing in the literature. Furthermore, our study differs from past analytical studies because, as to the best of the authors’ knowledge, is the first to provide independent (not in comparison to other treatment) statistical results regarding the effectiveness of each TE treatment.
Materials and Methods: Major medical databases such as PubMed, Scopus, Embase, Web of Science, Google Scholar, Cochrane Library, BIOSIS, and EBSCO were searched. The overall search process was conducted in 3 stages.
Results: A total of 40 studies met the inclusion criteria and were included in this study. Out of those 40 meta-analyses, a total of 160 primary studies were screened in order to extract the data and perform a statistical analysis.
Conclusion: The present umbrella review underlines the efficiency of injection therapies, especially autologous blood, and platelet-rich plasma, while simultaneously proving the ineffectiveness of acupunc-ture and shock wave therapy as treatments for TE. Furthermore, the value of other known conservative treatment modalities, such as physical therapy, has been demonstrated.

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Autorzy i Afiliacje

Michał Bonczar

1 2

Patryk Ostrowski

1 2

Dawid Plutecki

2 3

Martyna Dziedzic

1 2

Jakub Florek

Weronika Michalik

Wojciech Przybycień

Paweł Depukat

Bartosz Rutowicz

Ewa Walocha

1 2

Mateusz Koziej

1 2

Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland
Youthoria. Youth Research Organization, Kraków, Poland
Collegium Medicum, Jan Kochanowski University, Kielce, Poland
Department of Orthopaedics and Traumatology, Rydygier Hospital, Brzesko, Poland

4 Analysis of biochemical parameters in an experimental model of chronic pancreatitis in rats

Patrycja Bronowicka-Adamska , Tomasz Hutsch , Dominika Szlęzak , Anna Bentke-Imiolek , Kinga Kaszuba , Piotr Ceranowicz , Beata Kuśnierz-Cabala

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 59-73 | DOI: 10.24425/fmc.2023.147214

Słowa kluczowe: chronic pancreatitis amylase lipases catalase superoxide dismutase reduced and oxidized glutathione dibutyltin dichloride

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Abstrakt

Background: Despite advanced research and great progress in understanding the chronic pancreatitis (CP) pathogenesis, no current causal treatment for the condition is available. For preclinical studies, the existence of a well-characterized CP animal model is essential.
The aim of the study was to assess the impact of chronic pancreatitis on the antioxidant enzymes activity in rat blood serum and on the level of glutathione (intracellular antioxidant) in rat pancreas.
Methods: The experiments were carried out on the Wistar Kyoto rats in two groups: control and study group (CP), in which chemical induction of pancreatitis with dibutyl dichloride was performed. Serum enzyme activities of amylase, lipase, catalase and superoxide dismutase were analyzed. The levels of the following biochemical parameters were also investigated: total protein, albumin, calcium, magnesium, and triglycerides. Levels of low-molecular-weight thiols: reduced (GSH) and oxidized (GSSG) glutathione, were determined in pancreatic homogenates.
Results: Histopathological imaging of rat pancreatic parenchyma with induced inflammation confirmed focal lymphocytic interstitial chronic pancreatitis with fibrosis features and mild parenchymal atrophy, as well as pancreatic islets degeneration. In the CP group, we observed a statistically significant decrease in serum amylase and lipase activities and in total protein/albumin levels. Also, the elevated catalase activity was registered. In CP rats’ tissues, we observed a 15-fold reduction in GSH levels. The other examined parameters remained unchanged. Clinically relevant are hypoalbuminemia and a moderate decrease in lipase activity. The described changes are most probably indicative of the impaired exocrine pancreas function, however without organ failure features.

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Autorzy i Afiliacje

Patrycja Bronowicka-Adamska

Tomasz Hutsch

Dominika Szlęzak

Anna Bentke-Imiolek

Kinga Kaszuba

Piotr Ceranowicz

Beata Kuśnierz-Cabala

Chair of Medical Biochemistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
Department of Pathology and Veterinary Diagnostics, Institute of Veterinary Medicine, Warsaw University of Life Sciences, Warsaw, Poland
Department of Physiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland

5 The autonomic nervous system in anorexia nervosa — an implication for the fat tissue

Andrzej Boryczko , Kamil Skowron , Magdalena Kurnik-Łucka , Krzysztof Gil

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 75-90 | DOI: 10.24425/fmc.2023.147215

Słowa kluczowe: anorexia nervosa eating disorders autonomic nervous system heart rate variability adipose tissue

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Abstrakt

Eating disorders are a heterogeneous group of diseases affecting mainly young people in devel-oped countries. Among them, anorexia nervosa (AN) is the one with the highest mortality, up to five times higher compared to healthy individuals. The etiology of this medical condition is complex and still un-certain. However, disturbances of the autonomic nervous system (ANS) and increased lipolysis resulting in a decrease of the adipose tissue volume are common findings among AN patients. Since ANS is directly connected to adipocyte tissue, thus significantly affecting the body’s metabolic homeostasis, we suspect that this relationship may be a potential pathophysiological underpinning for the development of AN. In this narrative review, we have analyzed scientific reports on ANS activity in AN considering different phases of the disease in humans as well as animal models. Due to the different effects of the disease itself on the ANS as well as specific variations within animal models, the common feature seems to be dysre-gulation of its function without the identification of one universal pattern. Nonetheless, higher norepi-nephrine concentrations have been reported in adipocyte tissue, suggesting local dominance of the sym-pathetic nervous system. Further studies should explore in depth the modulation of sympathetic in adipose tissue factor and help answer key questions that arise during this brief narrative review.

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Autorzy i Afiliacje

Andrzej Boryczko

1 2

Kamil Skowron

Magdalena Kurnik-Łucka

Krzysztof Gil

Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland
Doctoral School of Medical and Health Sciences, Jagiellonian University Medical College, Kraków, Poland

6 A proposal for a database of sounds generated by temporomandibular joints and a tool for automated diagnosis based on an RDC/TMD questionnaire

Justyna Grochala , Marcin Kajor , Małgorzata Pihut , Jolanta E. Loster

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 91-102 | DOI: 10.24425/fmc.2023.147216

Słowa kluczowe: auscultation TMJ temporomandibular joints TMJ sounds database TMD temporomandibular disorder RDC/TMD

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Abstrakt

The prevalence of TMD indicates a need to develop new tools that are useful in the case of screening examinations. These methods can support diagnosis at the early stage of the disorder. The purpose of this research was to develop a comprehensive tool that would function as both a database of sounds generated by TMJ and as software which facilitates automated diagnosis. The software would also use the data from the RDC/TMD questionnaire. Such a tool may significantly reduce the time spent by dentists on making manual RDC/TMD diagnoses. Moreover, this solution would enable dentists who do not specialise in TMD to make effective diagnoses. 95 patient took part in the clinical examination: 30 man and 65 females. The mean age of the participants was 33 years. Patients participating in the clinical process were examined according to the Polish version of the RDC/TMD questionnaire (Axis I and Axis II). Subsequently, all subjects were auscultated with an electronic stethoscope. An application has been im-plemented based on the RDC/TMD diagnostic flow chart. This tool was used for the automated generation of RDC/TMD diagnoses for all patients. As a result of the kind permission and participation of the patients under examination, it was possible to store records of ninety-five people. Each record contains RDC/TMD questionnaire data, auscultation signals and RDC/TMD diagnoses. For the first time, a database was created that has the potential to facilitate further examination. However, the developed system is universal and can therefore be adapted to new DC/TMD criteria.

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Autorzy i Afiliacje

Justyna Grochala

Marcin Kajor

Małgorzata Pihut

Jolanta E. Loster

Jagiellonian University Medical College, Department of Dental Prosthetics and Orthodontics, Institute of Dentistry, Kraków, Poland
AGH University of Science and Technology, Department of Automatics, Computer Science and Biomedical Engineering, Faculty of Electrical Engineering, Kraków, Poland
Prof. Loster’s Orthodontics, Kraków, Poland

7 Treatment options for oropharyngeal carcinoma — An umbrella review

Dawid Plutecki , Elżbieta Szczepanek , Małgorzata Szczepanek , Ameen Nasser , Paweł Hajdyła , Paweł Wrona

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 103-124 | DOI: 10.24425/fmc.2023.147217

Słowa kluczowe: ropharyngeal carcinoma squamous cell carcinoma human papillomavirus cancer treatment

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Abstrakt

Introduction: Our umbrella review aimed to summarize and revisit the evidence from all of the meta-analyses and systematic reviews regarding the treatments of oropharyngeal squamous cell carci-noma (OPSCC).
Materials and Methods: Major medical databases such as PubMed, Scopus, Embase, Web of Science, Google Scholar, Cochrane Library, BIOSIS, and EBSCO were searched. The overall search process was conducted in 3 stages.
Results: Finally, a total of 28 studies met the inclusion criteria and were included in this study. Out of those 28 meta-analyses, a total of 315 primary studies were screened in order to extract the data and perform the statistical analysis. In total, data from 22,619 patients was analyzed.
Conclusion: The main objective of the present umbrella review was to summarize and analyze all of the evidence-based data provided by numerous meta-analyses and systematic reviews regarding the treatment of OPSCC. Our study delivers the most up-to-date and evidence-based results regarding the different therapeutic modalities of this malignancy in one concise review, making it the ultimate tool for physicians treating OPSCC.

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Autorzy i Afiliacje

Dawid Plutecki

Elżbieta Szczepanek

2 3

Małgorzata Szczepanek

Ameen Nasser

Paweł Hajdyła

Paweł Wrona

Collegium Medicum, Jan Kochanowski University, Kielce, Poland
Department of Otolaryngology and Head and Neck Surgery, Medical University of Warsaw, Warsaw, Poland
Doctoral School in Medical Sciences and Health Sciences, Jagiellonian University Medical College, Kraków, Poland
Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland

8 Endoscopic treatment of cystic craniopharyngiomas in elderly patients. Report of three cases with a review

Krzysztof Stachura , Ewelina Grzywna , Maciej J. Frączek

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 125-131 | DOI: 10.24425/fmc.2023.147218

Słowa kluczowe: cystic craniopharyngioma neuroendoscopy transcortical transventricular approach elderly

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Abstrakt

Craniopharyngiomas are rare tumors with peak incidence between 5–14 and between 65–74 years of age. Treatment of choice is surgical resection, sometimes associated with radiation therapy. Complete tumor resection may be challenging. Radical surgery is particularly risky in older patients. Authors evaluate three cases of large cystic craniopharyngioma in patients in their 7th and 8th decade of life operated with the use of endoscopic technique. The postoperative follow-up period in which out-patient controls with imaging examinations were performed was up to 6 years. Symptoms of intracranial hypertension resolved in all patients in the immediate postoperative period. Visual acuity improved in two patients. No cases of aseptic meningitis have been reported. One patient underwent subsequent radio-therapy. The well-being of the operated patients continued.
Endoscopic transventricular approach to cystic craniopharyngiomas may be a safe and effective approach in older patients, being an alternative to microsurgical procedures.

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Autorzy i Afiliacje

Krzysztof Stachura

Ewelina Grzywna

Maciej J. Frączek

Department of Neurosurgery and Neurotraumatology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland

9 What is the safest method of orthodontic debonding- a systematic review of the literature

Marta Gibas-Stanek , Piotr Pełka , Małgorzata Pihut

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 133-156 | DOI: 10.24425/fmc.2023.147219

Słowa kluczowe: orthodontic debonding enamel cracks orthodontic brackets debonding pliers

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Abstrakt

The objective of this study was to review the current knowledge based on in vitro and in vivo studies, that evaluated the enamel damage connected with removal of metal and ceramic orthodontic brackets taking into account different debonding methods. Brackets fracture was also assessed. The protocol for this study was constructed according to the PRISMA statement. The literature review was performed in MEDLINE via PubMed, Cochrane and Scopus databases in May 2021. The searching was repeated in Journal of Stomatology, Orthodontic Forum and grey literature was screened using Google Scholar. Out of eligible studies 207 were screened by title and abstract, 85 subjected to full-text analysis and 30 were qualified for the research. The prevalence of enamel fracture ranged from 0 to 94.4%. The results of our review do not allow to identify the manual method of debonding that minimizes the risk of enamel damage. Thermal method and laser irradiation reduce the risk of enamel fracture.

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Autorzy i Afiliacje

Marta Gibas-Stanek

Piotr Pełka

Małgorzata Pihut

Department of Prosthodontics and Orthodontics, Dental Institute, Jagiellonian University Medical College, Kraków, Poland
5th Military Clinical Hospital with Policlinic, Orthodontic Clinic, Kraków, Poland

10 Anatomical features of the mandibular canal and their clinical significance — review of literature

Janusz Skrzat , Wojciech Ryniewicz , Grzegorz Goncerz , Magdalena Kozerska

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 3 | 157-170 | DOI: 10.24425/fmc.2023.147220

Słowa kluczowe: mandibular canal inferior alveolar canal mandible

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Abstrakt

The clinical issues related to the anatomical variation of the mandibular canal have been extensively analyzed since the 19th century. Evolving dentistry techniques and advancements in the prosthetics forced to collect detailed information about anatomical variations of the mandibular canal due to its neurovascular content. Therefore, its radiographic imaging became an essential part of the oral surgery, in order to avoid complications resulted from an accidental damage of the mandibular canal.

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Autorzy i Afiliacje

Janusz Skrzat

Wojciech Ryniewicz

Grzegorz Goncerz

Magdalena Kozerska

Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
Department of Prosthodontics and Orthodontics, Institute of Dentistry, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland

Instrukcja dla autorów

Manuscripts will be considered for publication in the form of Original Articles or Reviews. Submitted work must comply with ethical policy, which is based on the Committee on Publication Ethics (COPE) guidelines on good publication. (http://publicationethics.org/). Only manuscripts that are previously unpublished, and are not offered simultaneously elsewhere will be considered.
SUBMISSION
Folia Medica Cracoviensia only accepts electronic submission via e-mail at folmedcrac@pan.pl. Manuscripts will be assigned a unique manuscript number that must be quoted in correspondence. Papers and Reviews are refereed by experts in the field; the Editors reserve the right to reject an article without review. Please submit your covering letter or comments to the Editor as well as the names of two potential referees (including name, affiliation, and e-mail address). Currently, Authors have the only option to publish their articles in printed version. The online version will be available soon.
Original Articles
Original Articles describe the results of basic or clinical studies. The length of all Original Articles is limited to 6000 words, excluding acknowledgements and disclosures, references, tables, figures, table legends and figure legends. Please limit the number of figures and tables to a maximum of eight (e.g. four figures and four tables). Color figures can be included as necessary; however authors will be charged a fee (for details please contact editorial office).
Review Articles
Topical reviews of basic or clinical areas are invited by the Editor. Manuscript length is limited to 5000 words and 50 references. All Review articles are subject to review.
Language
The Folia Medica Cracoviensia uses American spelling. Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English.

The complete set of instructions for Authors can be downloaded here as a PDF file: http://www.fmc.cm-uj.krakow.pl/pdf/Author_Guidelines_Folia_2017_Jul_31_KG1.pdf