Nauki Medyczne

Folia Medica Cracoviensia

ISSN

ISSN 0015-5616

Wydawcy

Oddział PAN w Krakowie; Uniwersytet Jagielloński – Collegium Medicum

Editorial Board:

Editor-in-Chief
dr hab. Krzysztof Gil, prof. UJ, Department of Pathophysiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0002-4732-7698

Vice Editor-in-Chief
Prof. Andrzej Surdacki, 2nd Department of Cardiology, Institute of Cardiology, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-7949-3140

Secretary Editor
Prof. Beata Kuśnierz – Cabala, Department of Diagnostics, Jagiellonian University Medical College, Kraków, Poland
ORCID 0000-0001-8639-5688

Editorial Board Members:

Prof. Benjamin Chain, Department of Infection and Immunity, University College London, London, England

Prof. Paul Enck, Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tübingen, Tübingen Germany

Prof. Tomasz Grodzicki, Department of Internal Medicine and Gerontology, Jagiellonian University Medical College, Kraków, Poland

Prof. Kalina Kawecka-Jaszcz, 1st Department of Cardiology, Interventional Electrocardiology and Hypertension, Jagiellonian University Medical College, Kraków, Poland

Prof. Maciej Małecki, Department of Metabolic Diseases, Jagiellonian University Medical College, Kraków, Poland

Prof. Janusz Marcinkiewicz, Department of Immunology, Jagiellonian University Medical College, Kraków, Poland

Prof. Franz H. Messerli, Swiss Cardiovascular Center, University of Bern, Switzerland and Department of Cardiology, Icahn School of Medicine, Mount Sinai Health Center, New York, USA

Prof. Jacek Musiał, 2nd Department of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland

Prof. Wiesław Pawlik, Department of Physiology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jacek J. Pietrzyk, 1st Department of Children's Diseases and the Department of Pediatrics, Jagiellonian University Medical College, Kraków, Poland

Prof. Władysław Sułowicz, Department of Nephrology, Jagiellonian University Medical College, Kraków, Poland

Prof. Jerzy A. Walocha, Department of Anatomy, ,Jagiellonian University Medical College, Kraków, Poland

Adres redakcji
ul. Czysta 18
31-121 Kraków
e-mail: folmedcrac@pan.pl

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- Vol. 63
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Zawartość

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4

1 Differences in the cardiovascular hemodynamic response between the Valsalva and Reverse Valsalva Maneuvers in healthy subjects

Andrzej Boryczko , Agata Furgała , Michał Jurczyk , Karolina Augustyn , Krzysztof Gil

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 5-25 | DOI: 10.24425/fmc.2023.148754

Słowa kluczowe: supraventricular tachycardia Vagal maneuver Reverse Valsalva autonomic nervous system

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Abstrakt

Background: The Valsalva Maneuver (VM) is the first-line treatment for paroxysmal supra-ventricular tachycardia, but a recent, novel, and efficient tool to restore sinus rhythm has been described, i.e., the Reverse Valsalva (RV). This study aims to compare changes in cardiovascular hemodynamics and autonomic system activity (ANS) based on heart rate variability (HRV) analysis during both maneuvers.
Methods: Fifteen healthy participants performed the VM and RV maneuvers three times in a sitting position for durations of 15 s and 10 s, respectively. Blood pressure (BP) and heart rate (HR) were continuously monitored before, during and after the tests. Autonomic system activity was evaluated using frequency-domain analysis of HRV.
Results: The decrease in HR from baseline to the lowest values, expressed as a ratio, was similar during both maneuvers (0.81 during the RV vs. 0.79 during the VM, p = 0.27). However, the final lowest HR in response to the RV was higher than that in response to the VM, 70/min vs. 59/min (p <0.001). The activation of the autonomic nervous system during the most bradycardic phase of the RV (phase II) and VM (phase IV) showed that the total power of HRV was less prominent during the RV than during the VM (p <0.012), with similar levels of parasympathetic activation. Conclusions: Our results showed less HR slowdown during the RV than during the VM. The changes in HRV parameters during both procedures in particular phases of the RV and VM suggest that the auto-nomic nervous system is activated alternately, so these tests can be used complementarily in a clinical setting with different results.

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Autorzy i Afiliacje

Andrzej Boryczko

1 2

Agata Furgała

e-mail:

ORCID:

Michał Jurczyk

Karolina Augustyn

Krzysztof Gil

Department of Pathophysiology, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland
Doctoral School of Medical and Health Sciences, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland

2 Suture-like pattern formation in the pterygospinous bridge of the human sphenoid bone

Janusz Skrzat , Grzegorz Goncerz

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 27-33 | DOI: 10.24425/fmc.2023.148755

Słowa kluczowe: pterygospinous bridge pterygospinous ligament pterygoid process sphenoid bone

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Abstrakt

The paper presents an anatomical study involving rare variations in the pterygospinous bridges found in Mongolian skulls. These structures extend between the lateral pterygoid plate and the sphenoid spine. Particularly interesting is the division of these bridges into two distinct parts of the similar length. The junctions within these structures resemble morphological patterns characteristic for the plain and zigzag sutures, which articulate the cranial bones.

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Autorzy i Afiliacje

Janusz Skrzat

Grzegorz Goncerz

Department of Anatomy, Faculty of Medicine, Jagiellonian University Medical College, Kraków, Poland

3 Patient Targeted Googling by nurses and midwives in Poland

Patrycja Zurzycka , Katarzyna Wojtas , Zofia Musiał , Grażyna Puto , Katarzyna Czyżowicz

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 35-47 | DOI: 10.24425/fmc.2023.148756

Słowa kluczowe: Internet Patient Targeted Googling nurses midwives

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Abstrakt

Introduction: Patient Targeted Googling (PTG) is not a new phenomenon, but in Poland — according to the information available to the authors — there has been no research in this area among nurses and midwives. The above-mentioned activity is associated with many doubts and concerns of legal and ethical issues, and therefore there is a need to explore it.
Objective: The aim of this study was to assess the prevalence of PTG among nurses and midwives in Poland.
Material and Methods: The study conducted among 300 working nurses and midwives used a diag-nostic survey based on the author’s survey questionnaire. Statistical analysis was performed using PQStat version: 1.8.4.142. Mann–Whitney U tests, chi^2 and Fisher’s correlations were used. The significance level was adopted at p <0.05 and highly significant at p <0.01.
Results: The respondents’ reasons for patient targeted googling were mainly lack of other sources of information, controlling adherence to recommendations, ascertaining the patient’s mental disorders, behavior, substance abuse status and physical appearance. PTG without informing the patient was con-sidered unethical and likely to violate the principle of informed consent and privacy. Respondents ex-pressed the need for PTG training.
Conclusions: The study presents the prevalence of PTG phenomenon among Polish nurses and mid-wives along with the different determinants of this activity.

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Autorzy i Afiliacje

Patrycja Zurzycka

Katarzyna Wojtas

Zofia Musiał

Grażyna Puto

Katarzyna Czyżowicz

Department of Clinical Nursing, Institute of Nursing and Midwifery, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland
Department of Internal Medicine and Community Nursing, Faculty of Health Sciences, Jagiellonian University Medical College, Kraków, Poland

4 Symptomatic Intraparenchymal Epididymal Cysts: Description of 11 cases

Evangelia Schoina , Ioanna Gkalonaki , Ioannis Trevlias , Christina Panteli , Ioannis Patoulias

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 49-55 | DOI: 10.24425/fmc.2023.148757

Słowa kluczowe: cyst epididymis painful scrotum male adolescence

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Abstrakt

Epididymal cysts are benign cystic formations of the epididymis that usually appear in adoles-cence or early adulthood. Their frequency doubles after the age of 14–15. Obstruction in the epididymal efferent ductules with subsequent prostenotic dilatation of them, as well as dysgenesis due to hormonal disorders during fetal or postnatal life, are possible. At the 1st Department of Pediatric Surgery of A.U.Th. we treated 11 cases of boys at the age of 11–16 who presented with acute scrotum because of an epididymal cyst. The diagnosis was confirmed by ultrasound scanning . Due to persistent symptomatology, patients underwent surgical exploration and removal of the cyst. The postoperative care of the patients was uncomplicated with immediate remission of symptoms. In one case, ipsilateral acute epididymitis oc-curred after 10 days, which was successfully treated with antibiotic therapy. It is reported that approxi-mately 50% of epididymal cysts involute within an average of 17 months. In conclusion, using the data obtained from the review ,of the small in number of international bibliography studies, it is proposed conservative treatment of asymptomatic cysts with diameter smaller than 1 cm and surgical excision [1] of large asymptomatic cysts with diameter greater than 1 cm, which do not regress after a follow-up of 24–48 months, cysts, regardless of their diameter, responsible for persistent symptoms and in the manifestation of acute scrotal symptoms due to inflammation, intravesical bleeding or secondarily torsion of the epi-didymis.

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Autorzy i Afiliacje

Evangelia Schoina

Ioanna Gkalonaki

e-mail:

ORCID:

Ioannis Trevlias

Christina Panteli

Ioannis Patoulias

First Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “G. Gennimatas”, Thessaloniki, Greece

5 HSPB1 mutation causing distal Hereditary Motor Neuropathy type 2B in a Polish family

Katarzyna Homa , Kamila Żur-Wyrozumska

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 57-61 | DOI: 10.24425/fmc.2023.148758

Słowa kluczowe: HSPB1 mutation dHMN distal Hereditary Motor Neuropathy 2B

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Abstrakt

The heat-shock protein beta-1 (HSPB1) is one of small heat-shock proteins that play an im-portant role in cell functioning by promoting correct folding of other proteins. The HSPB1 mutations are known to cause distal Hereditary Motor Neuropathy type 2B (dHMN2B) and Charcot-Marie-Tooth disease type 2F (CMT2F). More than 30 different mutations in the HSPB1 have been found in patients with CMT2F and dHMN2B. There are cases of the Thr151Ile HSPB1 mutation described in 4 countries: Croatia, Japan, France and Poland. In this paper we present a Polish family with p.Thr151Ile mutation causing distal hereditary motor neuropathy. A 48-year-old male patient presented progressive bilateral lower limb weakness and gait difficulty of typical onset. The presentation of the disease in his daughter, who carries the same mutation is yet uncertain. She has currently no clinical symptoms of the disease but registered mild muscle damage in EMG with correct conduction parameter in EMG.

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Autorzy i Afiliacje

Katarzyna Homa

Kamila Żur-Wyrozumska

2 3

Department of Neurology, The Gabriel Narutowicz Specialist Municipal Hospital, Kraków, Poland
Department of Neurology, The Józef Dietl Specialist Hospital, Kraków, Poland
Department of Medical Education, Jagiellonian University Medical College, Kraków, Poland

6 Academic Motivation and Quality of Life of Polish Medical Students

Dorota Zawiślak , Karolina Skrzypiec , Kamila Żur-Wyrozumska , Mariusz Habera , Grzegorz Cebula

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 63-80 | DOI: 10.24425/fmc.2023.148759

Słowa kluczowe: healthcare well-being learning medical schools

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Abstrakt

Background: The skills and attitudes of medical staff affect the quality of the healthcare system, hence the study of academic motivation and quality of life of medical students.
Materials and Methods: The study involved 203 students of the Jagiellonian University Medical College. Academic motivation was assessed using the Academic Motivation Scale and quality of life using the World Health Organization Quality of Life-BREF questionnaire. Academic Motivation Scale is based on the Self-Determination Theory, which distinguishes several dimensions of motivation arranged along self-determination continuum from amotivation, through extrinsic, controllable motivation, to intrinsic, autonomous motivation.
Results: For our students, the main reason for taking up studies was identified regulation, it means that they perceive studying as something important for them, giving more opportunities in the future. Next was intrinsic motivations to know, where gaining knowledge is a value in itself. The third was external regulation, which indicate that the choice of studies was regulated by the dictates of the environment or the desire to obtain a reward. Female students showed a more intrinsically motivational profile than male students. Motivation became less autonomous as the years of study progressed. Most students rated their quality of life as good or very good. There was weak correlation between students’ good quality of life and more self-determined academic motivation.
Conclusions: Our students are mainly intrinsically motivated, most of them positively assess the quality of life. A more autonomous approach to learning coexisted with a positive assessment of quality of life.

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Autorzy i Afiliacje

Dorota Zawiślak

Karolina Skrzypiec

Kamila Żur-Wyrozumska

Mariusz Habera

Grzegorz Cebula

Centre for Innovative Medical Education, Jagiellonian University Medical College, Kraków, Poland

7 Urachal remnants: from embryology to clinical practice

Ioanna Gkalonaki , Ioannis Patoulias , Michail Anastasakis , Christina Panteli , Dimitrios Patoulias

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 81-88 | DOI: 10.24425/fmc.2023.148760

Słowa kluczowe: patent urachus urachal sinus urachal cyst urachal diverticulum urachal remnants bladder outlet obstruction malignancy

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Abstrakt

The urachus is a tubular structure that is apparent on the third week and connects the ventral cloaca to the yolk sac, as a progression from the allantois. Following the normal regression procedure, the urachus remains as the median umbilical ligament.
Urachal remnants are present in 1.03% of paediatric patients while in 92.5% of cases represent incidental findings. Urachal anomalies are classified in four types as patent urachus (50–52%), urachal sinus (15%), urachal cyst (30%) and urachal diverticulum (3–5%). Ultrasound scan is the most commonly performed diagnostic imaging study.
In case of symptomatic urachal remnants, surgical excision is indicated. Asymptomatic urachal remnants that are diagnosed at the neonatal period or early infancy should be watched up to 6 months of age, as they are likely to resolve. In persistent or symptomatic urachal remnants there is a risk of inflammation or even malignancy development, therefore we believe that there is indication for preventive surgical excision that may be performed either open or laparoscopically or by robot-assisted laparoscopy.

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Autorzy i Afiliacje

Ioanna Gkalonaki

e-mail:

ORCID:

Ioannis Patoulias

Michail Anastasakis

Christina Panteli

Dimitrios Patoulias

First Department of Pediatric Surgery, Aristotle University of Thessaloniki, General Hospital “G. Gennimatas”, Thessaloniki, Greece
First Department of Internal Medicine, General Hospital “Hippokration”, Thessaloniki, Greece

8 Pelvic cavity and its spaces — anatomical overview

Tomasz Iskra , Krzysztof Balawender , Wojciech Przybycień , Bartosz Rutowicz , Małgorzata Mazur , Bernard Solewski , Karolina Brzegowy-Solewska , Piotr Litwa , Maciej Sychta , Jerzy Walocha

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | pelvic cavity | DOI: 10.24425/fmc.2023.148761

Słowa kluczowe: 89-98

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Abstrakt

Anatomical nomenclature commonly does not follow changes in the clinical language and demands. Therefore we tried to explain the pelvic relationships based on the changes that occur in the pelvis as well as to compare different nomenclatural strategies used in every day language. Courses of fasciae in the male and female pelvis are also considered.

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Autorzy i Afiliacje

Tomasz Iskra

Krzysztof Balawender

2 3 4

Wojciech Przybycień

Bartosz Rutowicz

Małgorzata Mazur

Bernard Solewski

Karolina Brzegowy-Solewska

Piotr Litwa

e-mail:

ORCID:

Maciej Sychta

Jerzy Walocha

Department of Anatomy, Jagiellonian University Medical College, Kraków, Poland
Department of Normal and Clinical Anatomy, Institute of Medical Science, Rzeszów University Medical College, Rzeszów, Poland
Department of Clinical Urology and Urological Oncology, Municipal Hospital of Rzeszów, Rzeszów, Poland
Faculty of Medicine, University Sulkhan-Saba Orbeliani LLC, Tbilisi, Georgia

9 Hypertension and Gastrointestinal Bleed in COVID-19 Patients: Associations with Mortality, Acute Kidney Injury, Vasopressor Use, and Mechanical Ventilation Use

Igor Brodskiy , Joshua Fogel , Aaron Douen , Justin Wagner , John Trillo

Folia Medica Cracoviensia | 2023 | Vol. 63 | No 4 | 99-108 | DOI: 10.24425/fmc.2023.148762

Słowa kluczowe: Gastrointestinal Hemorrhage hypertension COVID-19

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Abstrakt

There are mixed findings on the association of hypertension or gastrointestinal bleed (GIB) with mortality in COVID-19 patients but no research on the combination of both hypertension and GIB with mortality in COVID-19 patients. We study in COVID-19 patients the association of hypertension and GIB with mortality, acute kidney injury (AKI), vasopressor use, and/or mechanical ventilation. This is a retro-spective study of COVID-19 patients who were categorized into groups of no GIB/no hypertension (n = 653), yes hypertension/no GIB (n = 1,620), yes GIB/no hypertension (n = 104), or yes GIB/yes hypertension (n = 334). Covariates included demographics and medical history variables. In the multi-variate logistic regression analysis for the composite outcome of mortality, AKI, vasopressor use, and/or mechanical ventilation use, yes hypertension/no GIB (OR: 1.47, 95% CI: 1.13, 1.89, p <0.001) and yes GIB/ no hypertension (OR: 1.68, 95% CI: 1.02, 2.78, p <0.001) were each significantly positively associated with the composite outcome. The yes GIB/yes hypertension group was not significantly associated with the composite outcome. In conclusion, we found that hypertension or GIB alone were each significantly associated with increased odds for the composite outcome while having both hypertension and GIB was protective and not significantly associated with the composite outcome. We recommend that clin-icians be aware of such findings when treating patients with COVID-19, as those with both hypertension and GIB may not need as aggressive treatment as compared to those with either hypertension or GIB.

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Autorzy i Afiliacje

Igor Brodskiy

Joshua Fogel

e-mail:

ORCID:

Aaron Douen

Justin Wagner

John Trillo

Department of Internal Medicine, South Brooklyn Health, Brooklyn, New York, USA
Department of Management, Marketing and Entrepreneurship, Brooklyn College, Brooklyn, New York, USA

Instrukcja dla autorów

Manuscripts will be considered for publication in the form of Original Articles or Reviews. Submitted work must comply with ethical policy, which is based on the Committee on Publication Ethics (COPE) guidelines on good publication. (http://publicationethics.org/). Only manuscripts that are previously unpublished, and are not offered simultaneously elsewhere will be considered.
SUBMISSION
Folia Medica Cracoviensia only accepts electronic submission via e-mail at folmedcrac@pan.pl. Manuscripts will be assigned a unique manuscript number that must be quoted in correspondence. Papers and Reviews are refereed by experts in the field; the Editors reserve the right to reject an article without review. Please submit your covering letter or comments to the Editor as well as the names of two potential referees (including name, affiliation, and e-mail address). Currently, Authors have the only option to publish their articles in printed version. The online version will be available soon.
Original Articles
Original Articles describe the results of basic or clinical studies. The length of all Original Articles is limited to 6000 words, excluding acknowledgements and disclosures, references, tables, figures, table legends and figure legends. Please limit the number of figures and tables to a maximum of eight (e.g. four figures and four tables). Color figures can be included as necessary; however authors will be charged a fee (for details please contact editorial office).
Review Articles
Topical reviews of basic or clinical areas are invited by the Editor. Manuscript length is limited to 5000 words and 50 references. All Review articles are subject to review.
Language
The Folia Medica Cracoviensia uses American spelling. Authors for whom English is a second language may choose to have their manuscript professionally edited before submission to improve the English.

The complete set of instructions for Authors can be downloaded here as a PDF file: http://www.fmc.cm-uj.krakow.pl/pdf/Author_Guidelines_Folia_2017_Jul_31_KG1.pdf